DMH-1
Cat. No.：YN460012
CAS No. ：1206711-16-1
| 产品名称: | DMH-1 |
| CAS No.: | 1206711-16-1 |
| Chemical Name: | 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Synonyms: | DMH1 |
| 分子量: | 380.44 |
| 分子式: | C₂₄H₂₀N₄O |
| SMILES: | CC(C)OC1=CC=C(C2=CN3C(N=C2)=C(C4=CC=NC5=CC=CC=C45)C=N3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DMH-1 是一种有效的，具有选择性的BMP抑制剂，对 ALK1/ALK2/ALK3/ALK6的IC50值分别为 27/107.9/<5/47.6 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sakata, T., and Chen, J.K.Chemical 'Jekyll and Hyde's: Small-molecule inhibitors of developmental signaling pathwaysChem. Soc. Rev.40(8),4318-4331(2011)
Hao, J., Ho, J.N., Lewis, J.A., et al.In vivo structure activity relationship study of dorsomorphin analogs identifies selective VEGF and BMP inhibitorsACS Chem. Biol.5(2),245-253(2010)
Mohedas, A.H., Xing, X., Armstrong, K.A., et al.Development of an ALK2-biased BMP type I receptor kinase inhibitorACS Chem. Biol.8(6),1291-1302(2013)
Ao, A., Hao, J., Hopkins, C.R., et al.DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cellsPLoS One7(7),e41627(2012)
Neely, M.D., Litt, M.J., Tidball, A.M., et al.DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 expression during neural inductionACS Chem. Neurosci.3(6),482-491(2012)
Hao, J., Lee, R., Chang, A., et al.DMH1, a small molecule inhibitor of BMP type I receptors, suppresses growth and invasion of lung cancerPLoS One9(3),1-6(2014)
