ML347
Cat. No.：YN460013
CAS No. ：1062368-49-3
| 产品名称: | ML347 |
| CAS No.: | 1062368-49-3 |
| Chemical Name: | 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Synonyms: | LDN 193719 |
| 分子量: | 352.39 |
| 分子式: | C₂₂H₁₆N₄O |
| SMILES: | COC1=CC=C(C2=CN3C(N=C2)=C(C4=C5C=CC=NC5=CC=C4)C=N3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML347(DN193719)是ALK1/ALK2选择性抑制剂，IC50分别为46/32 nM，比对ALK3的抑制性高300倍。 |
| IC50和靶点: | [{name:"ALK1:46 nM (IC50)"},{name: "ACVR1:32 nM (IC50)"},{name: "BMPR1A:10800 nM (IC50)"}] |
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Brivanlou, A.H., and Darnell, J.E., Jr.Signal transduction and the control of gene expressionScience295(5556),813-818(2002)
Engers, D.W., Frist, A.Y., Lindsley, C.W., et al.Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probeBioorg. Med. Chem. Lett.23(11),3248-3252(2013)
