R-268712
Cat. No.：YN460017
CAS No. ：879487-87-3
| 产品名称: | R-268712 |
| CAS No.: | 879487-87-3 |
| Chemical Name: | 4-[2-fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol |
| Synonyms: | R 268712,R268712 |
| 分子量: | 363.39 |
| 分子式: | C₂₀H₁₈FN₅O |
| SMILES: | FC1=C(C2=CN(CCO)N=C2)C=C(C3=CNN=C3C4=CC=CC(C)=N4)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | R-268712是一种有效的选择性ALK5抑制剂, IC50为2.5 nM。 |
| IC50和靶点: | [{name:"TGFBR1:2.5 nM (IC50)"},{name: "Smad3:10.4 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
H., T., M., K., M., E., et al.R-268712, an orally active transforming growth factor-β type I receptor inhibitor, prevents glomerular sclerosis in a Thy1 nephritis modelEur. J. Pharmacol.734,60-66(2014)
