RepSox
Cat. No.：YN460018
CAS No. ：446859-33-2
| 产品名称: | RepSox |
| CAS No.: | 446859-33-2 |
| Chemical Name: | 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
| Synonyms: | E-616452; SJN 2511 |
| 分子量: | 287.32 |
| 分子式: | C₁₇H₁₃N₅ |
| SMILES: | CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RepSox 是一种有效，选择性的TGFβR-1/ALK5抑制剂， 抑制ALK5自磷酸化，IC50为 4 nM。 |
| IC50和靶点: | [{name:"ALK5:4 nM (IC50)"}] |
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| Solvent & Solubility: |
Gellibert, F., Wollven, J., Fouchet, M.H., et al.Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-β type I receptor inhibitorsJ. Med. Chem.47(18),4494-4506(2004)
Ichida, J.K., Blanchard, J., Lam, K., et al.A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing NanogCell Stem Cell5(5),491-503(2009)
