Galunisertib
Cat. No.：YN460019
CAS No. ：700874-72-2
| 产品名称: | Galunisertib |
| CAS No.: | 700874-72-2 |
| Chemical Name: | 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide |
| Synonyms: | LY2157299 |
| 分子量: | 369.42 |
| 分子式: | C₂₂H₁₉N₅O |
| SMILES: | CC1=CC=CC(C2=NN3C(CCC3)=C2C4=CC=NC5=C4C=C(C=C5)C(N)=O)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Galunisertib (LY2157299) 是一种选择性的TGF-β 受体 I 型 (TGF-βRI) 激酶抑制剂，IC50为 56 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mundla, S.R.A pyridin quinolin substituted pyrrolo [1,2-B] pyrazole monohydrate as TGFβinhibitorPCT/US2006/025377,1-13(2014)
Bhola, N.E., Balko, J.M., Dugger, T.C., et al.TGF-β inhibition enhances chemotherapy action against triple-negative breast cancerJ. Clin. Invest.123(3),1348-1358(2013)
Dituri, F., Mazzocca, A., Peidrò, F.J., et al.Differential inhibition of the TGF-β signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor type IIPLoS One8(6),e67109(2013)
