SD-208
Cat. No.：YN460020
| 产品名称: | SD-208 |
| CAS No.: | 627536-09-8 |
| Chemical Name: | 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine |
| Synonyms: | SD208,ALK5 Inhibitor V |
| 分子量: | 352.75 |
| 分子式: | C₁₇H₁₀ClFN₆ |
| SMILES: | FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(NC4=CC=NC=C4)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SD-208 是一种选择性的TGF-βRI (ALK5)抑制剂，IC50值为 48 nM，对其选择性是对 TGF-βRII 的 100 多倍。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
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Uhl, M., Aulwurm, S., Wischhusen, J., et al.SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivoCancer Res.64(21),7954-7961(2004)
Leung, S.Y., Niimi, A., Noble, A., et al.Effect of transforming growth factor-β receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodelingJ. Pharmacol. Exp. Ther.319(2),586-594(2006)
Driesen, R.B., Nagaraju, C.K., Abi-Char, J., et al.Reversible and irreversible differentiation of cardiac fibroblastsCardiovasc. Res.101(3),411-422(2014)
Kapoun, A.M., Gaspar, N.J., Wang, Y., et al.Transforming growth factor-β receptor type 1 (TGFβRI) kinase activity but not p38 activation is required for TGFβRI-induced myofibroblast differentiation and profibrotic gene expressionMol. Pharmacol.70(2),518-531(2006)
