LY-364947
Cat. No.：YN460021
| 产品名称: | LY-364947 |
| CAS No.: | 396129-53-6 |
| Chemical Name: | 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline |
| Synonyms: | HTS466284 |
| 分子量: | 272.30 |
| 分子式: | C₁₇H₁₂N₄ |
| SMILES: | C1(C2=CNN=C2C3=NC=CC=C3)=CC=NC4=CC=CC=C14 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY-364947 (HTS466284) 是一种有效的，ATP 竞争性的TGFβR-I抑制剂，IC50值为 59 nM，是对 TGFβR-II 选择性的 7 倍。 |
| IC50和靶点: | |
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Sawyer, J.S., Anderson, B.D., Beight, D.W., et al.Synthesis and activity of new aryl- and heteroaryl-substituted pyrazoleInhibitors of the transforming growth factor-b type I receptor kinase domainJ. Med. Chem.46(19),3953-3956(2003)
Li, H.y., Wang, Y., Heap, C.R., et al.Dihydropyrrolopyrazole transforming growth factor-b type I receptor kinase domain inhibitors: A novel benzimidazole series with selectivity versus transforming growth factor-b type II receptor kinase and mixed lineage kinase-7J. Med. Chem.49,2138-2142(2006)
Shiou, S.R., Datta, P.K., Dhawan, P., et al.Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factoJ. Biol. Chem.281(45),33971-33981(2006)
