BIBF0775
Cat. No.：YN460026
CAS No. ：334951-90-5
| 产品名称: | BIBF0775 |
| CAS No.: | 334951-90-5 |
| Chemical Name: | (3Z)-N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide |
| Synonyms: | BIBF0775; BIBF-0775; BIBF 0775; |
| 分子量: | 494.63 |
| 分子式: | C₃₁H₃₄N₄O₂ |
| SMILES: | O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(C3=CC=CC=C3)\NC4=CC=C(CN5CCCCC5)C=C4)N(CC)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIBF0775是有效，选择性的TGFβI型受体 (Alk5)的抑制剂，IC50为34 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Roth, G.J., Heckel, A., Brandl, T., et al.Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI)J. Med. Chem.53(20),7287-7295(2010)
Roth, G.J., Heckel, A., Colbatzky, F., et al.Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120)J. Med. Chem.52(14),4466-4480(2009)
