LDN-212854
Cat. No.：YN460027
CAS No. ：1432597-26-6
| 产品名称: | LDN-212854 |
| CAS No.: | 1432597-26-6 |
| Chemical Name: | 5-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
| Synonyms: | BMP Inhibitor III |
| 分子量: | 406.48 |
| 分子式: | C₂₅H₂₂N₆ |
| SMILES: | C12=C(C3=C4N=CC(C5=CC=C(N6CCNCC6)C=C5)=CN4N=C3)C=CC=C1N=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LDN-212854是新型BMP抑制剂，对ALK2的IC50为1.3 nM，比对ALK1，ALK3，ALK4和ALK5的抑制性高2，66，1641和7135倍。 |
| IC50和靶点: | [{name:"ACVR1:1.3 nM (IC50)"},{name: "ALK1:2.4 nM (IC50)"},{name: "BMPR1A:85.8 nM (IC50)"},{name: "ALK4:2133 nM (IC50)"},{name: "ALK5:9276 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mohedas, A.H., Xing, X., Armstrong, K.A., et al.Development of an ALK2-biased BMP type I receptor kinase inhibitorACS Chem. Biol.8(6),1291-1302(2013)
