LDN-214117
Cat. No.：YN460028
CAS No. ：1627503-67-6
| 产品名称: | LDN-214117 |
| CAS No.: | 1627503-67-6 |
| Chemical Name: | 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-piperazine |
| Synonyms: | LDN-214117;1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine;1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine;1-{4-[6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine;compound 10 [PMID: 25101911] |
| 分子量: | 419.52 |
| 分子式: | C₂₅H₂₉N₃O₃ |
| SMILES: | CC(C(C1=CC(OC)=C(OC)C(OC)=C1)=C2)=NC=C2C3=CC=C(N4CCNCC4)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LDN-214117是ALK2高效选择性抑制剂，IC50值为22nM,也能抑制BMP6，IC50值为100nM,对ALK5抑制力弱100倍。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mohedas, A.H., Wang, Y., Sanvitale, C.E., et al.Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutantsJ. Med. Chem.59(19),7900-7915(2014)
