Ataciguat
Cat. No.：YN322432
| 产品名称: | Ataciguat |
| CAS No.: | 254877-67-3 |
| Chemical Name: | 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]-benzamide |
| Synonyms: | HMR-1766 |
| 分子量: | 576.5 |
| 分子式: | C21H19Cl2N3O6S3 |
| SMILES: | O=S(N1CCOCC1)(C2=CC=C(NC(C3=CC(Cl)=CC=C3NS(C4=CC=C(Cl)S4)(=O)=O)=O)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ataciguat (HMR-1766) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 激活剂。Ataciguat 能够激活 sGC 的铁血红素铁氧化还原形式，刺激 cGMP 的产生。Ataciguat 具有血管舒张作用。 |
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Stasch, J.P., Pacher, P., and Evgenov, O.V.Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary diseaseCirculation123(20),2263-2273(2011)
Schindler, U., Strobel, H., Schönafinger, K., et al.Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclaseMol. Pharmacol.69(4),1260-1268(2006)
Zhou, Z., Pyriochou, A., Kotanidou, A., et al.Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stressAm. J. Physiol. Heart Circ. Physiol.295(4),H1763-H1771(2008)
