(E)-SIS3
Cat. No.：YN450072
| 产品名称: | (E)-SIS3 |
| CAS No.: | 521984-48-5 |
| Chemical Name: | SIS 3 |
| Synonyms: | SIS3,SIS3 盐酸盐,SIS3 HCl |
| 分子量: | 489.99 |
| 分子式: | C₂₈H₂₈ClN₃O₃ |
| SMILES: | [H]Cl.O=C(/C=C/C1=C(N(C2=NC=CC=C21)C)C3=CC=CC=C3)N4CC5=C(CC4)C=C(C(OC)=C5)OC.[E] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (E)-SIS3 是一种有效和选择性的Smad3抑制剂，抑制 Smad3 磷酸化的IC50为 3 μM。(E)-SIS3 通过 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
(1) Jinnin, M., et al. Mol.Pharmacol. 69 597 (2006). & (2) Di Bernardini, M., et al.: J.Biol.Chem. 289 3383 (2014).
