Halofuginone
Cat. No.：YN450144
CAS No. ：55837-20-2
规格
价格(RMB)
库存
| 产品名称: | Halofuginone |
| CAS No.: | 55837-20-2 |
| Chemical Name: | |
| Synonyms: | 常山酮; RU-19110 |
| 分子量: | 414.68 |
| 分子式: | C₁₆H₁₇BrClN₃O₃ |
| SMILES: | O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Halofuginone (RU-19110) 是 Febrifugine 的一种低毒性衍生物，可从Dichroa febrifuga中分离出来。Halofuginone 是一种 ATP 竞争性的脯氨酰-tRNA 合成酶 (prolyl-tRNA synthetase) 抑制剂，Ki为 18.3 nM。Halofuginone 是 I 型胶原 (type-I collagen) 合成的特异性抑制剂，并通过抑制TGF-β活性可减轻骨关节炎。 |
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