Halofuginone hydrobromide
Cat. No.：YN450145
CAS No. ：64924-67-0
规格
价格(RMB)
库存
| 产品名称: | Halofuginone hydrobromide |
| CAS No.: | 64924-67-0 |
| Chemical Name: | rel-7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone Hydrobromide; trans-(+/-)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2- |
| Synonyms: | 常山酮溴酸盐; RU-19110 hydrobromide |
| 分子量: | 495.59 |
| 分子式: | C₁₆H₁₈Br₂ClN₃O₃ |
| SMILES: | O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3.Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Halofuginone hydrobromide (RU-19110 hydrobromide) 是 Febrifugine 的一种低毒性衍生物，可从Dichroa febrifuga中分离出来。Halofuginone 是一种 ATP 竞争性的脯氨酰-tRNA 合成酶 (prolyl-tRNA synthetase) 抑制剂，Ki为 18.3 nM。Halofuginone 是 I 型胶原 (type-I collagen) 合成的特异性抑制剂，并通过抑制TGF-β活性可减轻骨关节炎。 |
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McIntosh, L., et al.: Biochem. Cell Biol., 73, 181 (1995), Leshem, Y., et al.: Exp. Cell Res., 274, 288 (2002),
