R-7050
Cat. No.：YN270095
CAS No. ：303997-35-5
| 产品名称: | R-7050 |
| CAS No.: | 303997-35-5 |
| Chemical Name: | 8-chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline |
| Synonyms: | TNF-α Antagonist III |
| 分子量: | 380.77 |
| 分子式: | C₁₆H₈ClF₃N₄S |
| SMILES: | FC(F)(C1=NN=C2N1C3=CC(Cl)=CC=C3N=C2SC4=CC=CC=C4)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | R-7050 (TNF-α Antagonist III) 是一种肿瘤坏死因子受体 (TNFR) 拮抗剂，对TNFα具有更高选择性。 |
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Gururaja, T.L., Yung, S., Ding, R., et al.A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1Chem. Biol.14(10),1105-1118(2007)
King, M.D., Alleyne, C.H., Jr., and Dhandapani, K.M.TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in miceNeurosci. Lett.542,92-96(2013)
Wu, W., and Zhang, H.Role of tumor necrosis factor-α and interleukin-1β in anorexia induction following oral exposure to the trichothecene deoxynivalenol (vomitoxin) in the mouseJ. Toxicol. Sci.39(6),875-886(2014)
