SPD304
Cat. No.：YN270096
| 产品名称: | SPD304 |
| CAS No.: | 869998-49-2 |
| Chemical Name: | 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-4H-1-benzopyran-4-one |
| Synonyms: | 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;CHEMBL255489;AC1NS1JP;SureCN1270919;MolPort-009-019-121;AG-L-65178;6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]- |
| 分子量: | 547.61 |
| 分子式: | C₃₂H₃₂F₃N₃O₂ |
| SMILES: | O=C1C(CN(C)CCN(C)CC2=CN(C3=CC=CC(C(F)(F)F)=C3)C4=C2C=CC=C4)=COC5=CC(C)=C(C)C=C15 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SPD304 是肿瘤坏死因子 α (TNF-α) 的选择性抑制剂，能够促进肿瘤坏死因子三聚体的分离，从而阻断其与受体间的相互作用。SPD304 体外抑制肿瘤坏死因子 α 和受体 1 间结合的IC50值为 22 µM。 |
| IC50和靶点: | |
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Beutler, B., Greenwald, D., Hulmes, J.D., et al.Identity of tumor necrosis factor and the macrophage-secreted factor cachectinNature316,552-554(1985)
Tracey, K.J., Beutler, B., Lowry, S.F., et al.Shock and tissue injury induced by recombinant human cachectinScience234,470-474(1986)
Bidgood, M.J., Jamal, O.S., Cunningham, A.M., et al.Type IIA secretory phospholipase A2 up-regulates cyclooxygenase-2 and amplifies cytokine-mediated prostaglandin production in human rheumatoid synoviocytesJ. Immunol.165,2790-2797(2000)
Thornberry, N.A., and Lazebnik, Y.Caspases: Enemies withinScience281(5381),1312-1316(1998)
Wallach, D., Varfolomeev, E.E., Malinin, N.L., et al.Tumor necrosis factor receptor and Fas signaling mechanismsAnnu. Rev. Immunol.17,133-167(1999)
He, M.M., Smith, A.S., Oslob, J.D., et al.Small-molecule inhibition of TNF-αScience310,1022-1025(2005)
