Roquinimex
Cat. No.：YN270265
CAS No. ：84088-42-6
| 产品名称: | Roquinimex |
| CAS No.: | 84088-42-6 |
| Chemical Name: | 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide |
| Synonyms: | Linomide; FCF89; ABR212616 |
| 分子量: | 308.33 |
| 分子式: | C₁₈H₁₆N₂O₃ |
| SMILES: | O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2)N(C)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Roquinimex (Linomide; PNU212616; ABR212616)是免疫刺激剂，能增强NK细胞活性和巨噬细胞的细胞毒性，抑制血管生成和TNF α的分泌。 |
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Ilbäck, N.G., Fohlman, J., Slorach, S., et al.Effects of the immunomodulator LS 2616 on lymphocyte subpopulations in murine coxsackievirus B3 myocarditisJ. Immunol.142(9),3225-3228(1989)
Xiao, Z.-Y., Zhou, W.-X., Zhang, Y.-X., et al.Roquinimex-mediated protection effect on the development of chronic graft-versus-host disease in mice is associated with induction of Th1 cytokine production and inhibition of proinflammatory cytokine productionLife Sci.81(19-20),1403-1410(2007)
Liu, Q., Wang, Y., Wan, M.X., et al.Roquinimex inhibits dextran sodium sulfate-induced murine colitisInflamm. Res.52(2),64-68(2003)
Gross, D.J., Reibstein, I., Weiss, L., et al.The antiangiogenic agent linomide inhibits the growth rate of Von Hippel-Lindau paraganglioma xenografts to miceClin. Cancer Res.5(11),3669-3675(1999)
