HI-TOPK-032
Cat. No.：YN290033
CAS No. ：487020-03-1
| 产品名称: | HI-TOPK-032 |
| CAS No.: | 487020-03-1 |
| Chemical Name: | N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide |
| Synonyms: | N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide;HI TOPK 032 |
| 分子量: | 369.40 |
| 分子式: | C₂₀H₁₁N₅OS |
| SMILES: | O=C(C1=CC=CS1)NC2=CC3=C(C#N)C4=NC5=CC=CC=C5N=C4N3C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HI-TOPK-032是有效特异的TOPK抑制剂。 |
| IC50和靶点: | |
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Kim, D.J., Li, Y., Reddy, K., et al.Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growthCancer Res.72(12),3060-3068(2012)
Li, Y., Kim, D.J., Ma, W., et al.Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structuresJ. Chem. Inf. Model51(11),2904-2914(2011)
Joel, M., Mughal, A.A., Grieg, Z., et al.Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivoMol. Cancer14,121(2015)
