Raltitrexed
Cat. No.：YN270076
CAS No. ：112887-68-0
| 产品名称: | Raltitrexed |
| CAS No.: | 112887-68-0 |
| Chemical Name: | N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic acid |
| Synonyms: | 雷替曲塞; ZD1694; D1694; ICI-D1694 |
| 分子量: | 458.49 |
| 分子式: | C₂₁H₂₂N₄O₆S |
| SMILES: | CC(NC1=O)=NC2=C1C=C(CN(C)C3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Raltitrexed是一种用于化疗的抗代谢药物，通过抑制胸苷酸合成酶起作用。 |
| IC50和靶点: | |
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Jackman, A.L., Taylor, G.A., Gibson, W., et al.ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical studyCancer Res.51(20),5579-5586(1991)
Qiu, C., Li, Y., Liang, X., et al.A study of peritoneal metastatic xenograft model of colorectal cancer in the treatment of hyperthermic intraperitoneal chemotherapy with RaltitrexedBiomed Pharmacother.92,149-156(2017)
