Nolatrexed dihydrochloride
Cat. No.：YN270081
| 产品名称: | Nolatrexed dihydrochloride |
| CAS No.: | 152946-68-4 |
| Chemical Name: | 2-amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone, dihydrochloride |
| Synonyms: | AG 337; Thymitaq |
| 分子量: | 357.26 |
| 分子式: | C₁₄H₁₄Cl₂N₄OS |
| SMILES: | [H]Cl.O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nolatrexed dihydrochloride (AG 337) 是一种非竞争性的胸苷酸合酶 (thymidylate synthase) 抑制剂，与该酶的叶酸辅因子结合位点相互作用，对人 thymidylate synthase 的Ki值为 11 nM。Nolatrexed dihydrochloride (AG 337) 能够在癌细胞 S 期诱导细胞周期停滞。具有抗癌活性。 |
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Webber, S., Bartlett, C.A., Boritzki, T.J., et al.AG337, a novel lipophilic thymidylate synthase inhibitor: In vitro and in vivo preclinical studiesCancer Chemother. Pharmacol.37(6),509-517(1996)
