Resmetirom
Cat. No.：YN480749
CAS No. ：920509-32-6
规格
价格(RMB)
库存
| 产品名称: | Resmetirom |
| CAS No.: | 920509-32-6 |
| Chemical Name: | 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile |
| Synonyms: | MGL-3196; VIA-3196 |
| 分子量: | 435.22 |
| 分子式: | C₁₇H₁₂Cl₂N₆O₄ |
| SMILES: | N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Resmetirom (MGL-3196) 是高度选择性的THR-β激动剂，EC50值为0.21 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kelly, M.J., Pietranico-Cole, S., Larigan, J.D., et al.Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemiaJ. Med. Chem.57(10),3912-3923(2014)
