Sobetirome
Cat. No.：YN481402
CAS No. ：211110-63-3
规格
价格(RMB)
库存
| 产品名称: | Sobetirome |
| CAS No.: | 211110-63-3 |
| Chemical Name: | 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-acetic acid |
| Synonyms: | GC-1; QRX-431 |
| 分子量: | 328.40 |
| 分子式: | C₂₀H₂₄O₄ |
| SMILES: | O=C(O)COC1=CC(C)=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sobetirome (GC-1) 是一种甲状腺激素受体 β (TRβ) 激动剂，Sobetirome可选择性结合到TRβ-1，EC50为 0.16 μM。 |
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Nguyen, N.-H., Apriletti, J.W., Cunha Lima, S.T., et al.Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitmentJ. Med. Chem.45(15),3310-3320(2002)
Johansson, L., Rudling, M., Scanlan, T.S., et al.Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid miceProc. Natl. Acad. Sci. USA102(29),10297-10302(2005)
Trost, S.U., Swanson, E., Gloss, B., et al.The thyroid hormone receptor-β-selective agonist GC-1 differentially affects plasma lipids and cardiac activityEndocrinology141(9),3057-3064(2000)
