9-Hydroxyellipticine hydrochloride
Cat. No.：YN290039
| 产品名称: | 9-Hydroxyellipticine hydrochloride |
| CAS No.: | 52238-35-4 |
| Chemical Name: | 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol, monohydrochloride |
| Synonyms: | 9-hydroxyellipticine HCl; 9-hydroxyellipticine hydrochloride; Hydroxyellipticine; 9-Hydroxyellipticin; NSC 210717; IGIG 929; IGIG929; IGIG-929; LS133324; LS-133324; LS 133324. |
| 分子量: | 298.77 |
| 分子式: | C₁₇H₁₅ClN₂O |
| SMILES: | OC1=CC2=C(NC3=C2C(C)=C(C=NC=C4)C4=C3C)C=C1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 9-Hydroxyellipticine hydrochloride 是Topo II和RyR的抑制剂。9-Hydroxyellipticine hydrochloride 具有抗肿瘤、抗氧化和释放儿茶酚胺的活性。 9-Hydroxyellipticine hydrochloride 对 Hela S-3 和293T 细胞的IC50值分别为1.6 μM 和1.2μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lesca, P., Rafidinarivo, E., Lecointe, P., et al.A class of strong inhibitors of microsomal monooxygenases: The ellipticinesChem. Biol. Interact.24(2),189-197(1979)
Monnot, M., Mauffret, O., Simon, V., et al.DNA-drug recognition and effects on topoisomerase II-mediated cytotoxicity. A three-mode binding model for ellipticine derivativesJ. Biol. Chem.266(3),1820-1829(1991)
Le Pecq, J.B., Grosse, C., Dat-Xuong, N., et al.Antitumor activity of 9-hydroxyellipticine (NSC 210717) ON L1210 mouse leukemia and the effect of route of injectionCancer Res.36(9 pt. 1),3067-3076(1976)
Cros, J., Thibault, A., and Dat-Xuong, N.Anti-inflammatory effect of hydroxy-9-ellipticineC. R. Acad. Sci. Hebd. Seances Acad. Sci. D.281(15),1139-1142(1975)
