Amonafide
Cat. No.：YN290090
CAS No. ：69408-81-7
| 产品名称: | Amonafide |
| CAS No.: | 69408-81-7 |
| Chemical Name: | 5-amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione |
| Synonyms: | 氨萘非特; AS1413 |
| 分子量: | 283.33 |
| 分子式: | C₁₆H₁₇N₃O₂ |
| SMILES: | O=C1N(C(C2=CC(N)=CC3=CC=CC1=C23)=O)CCN(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amonafide 是一种拓扑异构酶 II (topoisomerase II) 的抑制剂和 DNA 的嵌入剂，通过抑制 Topo II 与 DNA 的结合，来诱导凋亡信号通路的发生。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hsiang, Y.H., Jiang, J.B., and Liu, L.F.Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogsMol. Pharmacol.36(3),371-376(1989)
Chen, Z., Liang, X., Zhang, H., et al.A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosisJ. Med. Chem.53(6),2589-2600(2010)
Liu, Y., Norton, J.T., Witschi, M.A., et al.Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancerNeoplasia13(5),453-460(2011)
Li, M., Wang, Y., Ge, C., et al.Synthesis and biological evaluation of novel alkylated polyamine analogues as potential anticancer agentsEur. J. Med. Chem.143,1732-1743(2018)
