Belotecan hydrochloride
Cat. No.：YN290264
CAS No. ：213819-48-8
| 产品名称: | Belotecan hydrochloride |
| CAS No.: | 213819-48-8 |
| Chemical Name: | (4S)-4-ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]ethyl]-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, monohydrochloride |
| Synonyms: | CKD-602 |
| 分子量: | 469.96 |
| 分子式: | C₂₅H₂₈ClN₃O₄ |
| SMILES: | O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CCNC(C)C)C5=CC=CC=C5N=C4C3=C2)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Belotecan hydrochloride (CKD-602 hydrochloride) 是拓扑异构酶I (Topoisomerase I) 抑制剂，是一种合成的水溶性喜树碱衍生物。 |
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Lee, J.H., Lee, J.M., Kim, J.K., et al.Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitorArch. Pharm. Res.21(5),581-590(1998)
Lee, S., Ho, J.Y., Liu, J.J., et al.CKD-602, a topoisomerase I inhibitor, induces apoptosis and cell-cycle arrest and inhibits invasion in cervical cancerMol. Med.25(1),23(2019)
Chung, M.-K., Kim, J.-C., and Han, S.-S.Embryotoxic effects of CKD-602, a new camptothecin anticancer agent, in ratsReprod. Toxicol.20(1),165-173(2005)
