Exatecan Mesylate
Cat. No.：YN290278
CAS No. ：169869-90-3
| 产品名称: | Exatecan Mesylate |
| CAS No.: | 169869-90-3 |
| Chemical Name: | (1S,9S)-1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-10,13-dione, monomethanesulfonate |
| Synonyms: | DX8951f |
| 分子量: | 531.55 |
| 分子式: | C₂₅H₂₆FN₃O₇S |
| SMILES: | O=S(C)(O)=O.O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Exatecan Mesylate 是一种 DNA 拓扑异构酶 I (topoisomerase I) 抑制剂，IC50值为 2.2 μM (0.975 μg/mL)，可用于癌症研究。 |
| IC50和靶点: | [{name:"Topoisomerase I:0.975 μg/mL (IC50)"}] |
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| Solvent & Solubility: |
Mitsui, I., Kumazawa, E., Hirota, Y., et al.A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivoJpn. J. Cancer Res.86(8),776-782(1995)
Kumazawa, E., and Ochi, Y.DE-310, a novel macromolecular carrier system for the camptothecin analog DX-8951f: Potent antitumor activities in various murine tumor modelsCancer Sci.95(2),168-175(2004)
Conilh, L., Fournet, G., Fourmaux, E., et al.Exatecan antibody drug conjugates based on a hydrophilic polysarcosine drug-linker platformPharmaceuticals (Basel)14(3),247(2021)
