Genz-644282
Cat. No.：YN290385
CAS No. ：529488-28-6
| 产品名称: | Genz-644282 |
| CAS No.: | 529488-28-6 |
| Chemical Name: | 2,3-dimethoxy-12-[2-(methylamino)ethyl]-benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one |
| Synonyms: | Genz644282 |
| 分子量: | 407.42 |
| 分子式: | C₂₂H₂₁N₃O₅ |
| SMILES: | O=C1N(CCNC)C2=C(C=NC(C2=C3)=CC4=C3OCO4)C5=CC(OC)=C(OC)C=C15 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Genz-644282 是一种非喜树碱类拓扑异构酶 I (topoisomerase I) 抑制剂，可用于癌症研究。 |
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Ruchelman, A.L., Houghton, P.J., Zhou, N., et al.5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistanceJ. Med. Chem.48(3),792-804(2005)
Kurtzberg, L.S., Roth, S., Krumbholz, R., et al.Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatmentClin. Cancer Res.17(9),2777-2787(2011)
