LM22A-4
Cat. No.：YN380010
CAS No. ：37988-18-4
| 产品名称: | LM22A-4 |
| CAS No.: | 37988-18-4 |
| Chemical Name: | N1,N3,N5-tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide |
| Synonyms: | LM 22A4 |
| 分子量: | 339.34 |
| 分子式: | C₁₅H₂₁N₃O₆ |
| SMILES: | O=C(C1=CC(C(NCCO)=O)=CC(C(NCCO)=O)=C1)NCCO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LM22A-4 是一种特异性的tyrosine kinase receptor B激动剂，常用于神经系统疾病研究。 |
| IC50和靶点: | |
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Massa, S.M., Yang, T., Xie, Y., et al.Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodentsJ. Clin. Invest.120(5),1774-1785(2010)
Schmid, D.A., Yang, T., Ogier, M., et al.A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndromeJ. Neurosci.32(5),1803-1810(2012)
Simmons, D.A., Belichenko, N.P., Yang, T., et al.A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's diseaseJ. Neurosci.33(48),18712-18727(2013)
Han, J., Pollak, J., Yang, T., et al.Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic strokeStroke43(7),1918-1924(2012)
