Selitrectinib
Cat. No.：YN380020
CAS No. ：2097002-61-2
| 产品名称: | Selitrectinib |
| CAS No.: | 2097002-61-2 |
| Chemical Name: | (3aR,10R)-5-fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-12H-15,17-ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one |
| Synonyms: | LOXO-195 |
| 分子量: | 380.42 |
| 分子式: | C₂₀H₂₁FN₆O |
| SMILES: | FC1=CN=C(CC[C@H](N2)C)C([C@](CCC3)([H])N3C(C=CN4N=C5)=NC4=C5C2=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Selitrectinib (LOXO-195) 是一种二代原肌凝蛋白相关激酶(TRK)抑制剂，其对TRKA和TRKC的IC50值分别为 0.6 nM 和 <2.5 nM。 |
| IC50和靶点: | [{name:"TrkA:0.6 nM (IC50)"},{name: "TrkC:<2.5 nM (IC50)"}] |
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| Solvent & Solubility: |
Drilon, A., Nagasubramanian, R., Blake, J.F., et al.A next-generation TRK kinase inhibitor overcomes acquired resistance to prior TRK kinase inhibition in patients with TRK fusion-positive solid tumorsCancer Discov.7(9),963-972(2017)
