Repotrectinib
Cat. No.：YN380021
CAS No. ：1802220-02-5
| 产品名称: | Repotrectinib |
| CAS No.: | 1802220-02-5 |
| Chemical Name: | (7S,13R)-11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one |
| Synonyms: | TPX-0005 |
| 分子量: | 355.37 |
| 分子式: | C₁₈H₁₈FN₅O₂ |
| SMILES: | O=C1NC[C@H](C)OC2=CC=C(F)C=C2[C@@H](C)NC3=NC4=C1C=NN4C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Repotrectinib (TPX-0005) 是一种有效的ROS1(IC50=0.07 nM) 和TRK(对 TRKA/B/C 的IC50=0.83/0.05/0.1 nM) 抑制剂。Repotrectinib 有效抑制 WTALK(IC50=1.01 nM)。Repotrectinib 具有抗癌活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Karachaliou, N., Chaib, I., Cardona, A.F., et al.Common co-activation of AXL and CDCP1 in EGFR-mutation-positive non-smallcell lung cancer associated with poor prognosisEBioMedicine29,112-127(2018)
