ONO-7475
Cat. No.：YN380052
CAS No. ：1646839-59-9
| 产品名称: | ONO-7475 |
| CAS No.: | 1646839-59-9 |
| Chemical Name: | N-[5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-3-quinolinecarboxamide |
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| 分子量: | 562.57 |
| 分子式: | C₃₂H₂₆N₄O₆ |
| SMILES: | O=C(C1=CC2=C(N(C3=CC=CC=C3)C1=O)CCCC2=O)NC4=NC=C(OC5=CC=NC6=CC(OC)=C(OC)C=C56)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ONO-7475 是一种有效的、选择性的、具有口服活性的Axl/Mer抑制剂，IC50值分别为 0.7 nM 和 1.0 nM。ONO-7475 使 AXL 过表达的EGFR突变型 NSCLC 细胞对 EGFR-TKIs 敏感，抑制耐药细胞的产生和耐药性的维持。ONO-7475 联合 Osimertinib (HY-15772) 为EGFR突变非小细胞肺癌 (NSCLC) 的研究提供了一个光明的前景。 |
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Ruvolo, P.P., Ma, H., Ruvolo, V.R., et al.Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanismsHaematologica102(12),2048-2057(2017)
