Entrectinib
Cat. No.：YN380065
CAS No. ：1108743-60-7
| 产品名称: | Entrectinib |
| CAS No.: | 1108743-60-7 |
| Chemical Name: | N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-benzamide |
| Synonyms: | 恩曲替尼; NMS-E628; RXDX-101 |
| 分子量: | 560.64 |
| 分子式: | C₃₁H₃₄F₂N₆O₂ |
| SMILES: | O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5CCOCC5)C=C(N6CCN(C)CC6)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Entrectinib (NMS-E628) 是有效，有口服活性的且具有中枢神经活性的Trk,ROS1和ALK抑制剂，抑制 TrkA, TrkB, TrkC, ROS1 和 ALK 的IC50值分别为 1, 3, 5, 12 和 7 nM。具有抗肿瘤活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Siena, S., Drilon, A.E., Ou, S.H.I., et al.Enrectinib (RXDX-101), an oral pan-Trk, ROS1, and ALK inhibitor in patients with advanced solid tumors harboring gene rearrangements,(2015)
Ardini, E., Menichincheri, M., De Ponti, C., et al.Characterization of NMS-E628, a small molecule inhibitor of anaplastic lymphoma kinase with antitumor efficacy in ALK-dependent lymphoma and non-small cell lung cancer modelsMol. Cancer Res.8(12 suppl),A244(2009)
Sullivan, I., and Planchard, D.ALK inhibitors in non-small cell lung cancer: The latest evidence and developmentsTher. Adv. Med. Oncol.8(1),32-47(2016)
