Larotrectinib sulfate
Cat. No.：YN380068
CAS No. ：1223405-08-0
| 产品名称: | Larotrectinib sulfate |
| CAS No.: | 1223405-08-0 |
| Chemical Name: | LOXO 101 sulfate;(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide Sulfate |
| Synonyms: | LOXO-101 sulfate; ARRY-470 sulfate |
| 分子量: | 526.51 |
| 分子式: | C₂₁H₂₄F₂N₆O₆S |
| SMILES: | O=S(O)(O)=O.O=C(N1CC[C@H](O)C1)NC2=C3N=C(N4[C@@H](C5=CC(F)=CC=C5F)CCC4)C=CN3N=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) 是一种 ATP 竞争性的、口服选择性抑制剂，对原肌凝蛋白相关激酶(TRK)家族受体的三个亚型 (TRKA，B 和C) 具有纳摩尔级别的 50% 抑制浓度。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Anon.: Cancer Discovery, 6, 4 (2016)
Passiglia, F., et al.: Expert Opin. Investig. Drugs, 25, 385 (2016)
