GNF-5837
Cat. No.：YN380079
CAS No. ：1033769-28-6
| 产品名称: | GNF-5837 |
| CAS No.: | 1033769-28-6 |
| Chemical Name: | N-[3-[[2,3-dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-urea |
| Synonyms: | GNF 5837 |
| 分子量: | 535.49 |
| 分子式: | C₂₈H₂₁F₄N₅O₂ |
| SMILES: | O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C)C(NC3=CC(NC/4=O)=C(C=C3)C4=C\C5=CC=CN5)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNF-5837 是一种有效的，选择性的，口服生物利用的泛TRK抑制剂，在 Ba/F3 细胞中显示出抗增殖作用 (对Tel-TrkC,Tel-TrkB和Tel-TrkA的IC50值分别为 7 nM，9 nM 和 11 nM)。_x000D_ . |
| IC50和靶点: | [{name:"TrkB:9 nM (IC50)"},{name: "TrkC:7 nM (IC50)"},{name: "TrkA:11 nM (IC50)"}] |
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| Solvent & Solubility: |
Caporali, A., and Emanueli, C.Cardiovascular actions of neurotrophinsPhysiol. Rev.89(1),279-308(2009)
Liu, Q., Schwaller, J., Kutok, J., et al.Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemiaEMBO J.19(8),1827-1838(2000)
Albaugh, P., Fan, Y., Mi, Y., et al.Discovery of GNF-5837, a selective TRK inhibitor with efficacy in rodent cancer tumor modelsACS Med. Chem. Lett.3(2),140-145(2012)
