Belizatinib
Cat. No.：YN380125
CAS No. ：1357920-84-3
| 产品名称: | Belizatinib |
| CAS No.: | 1357920-84-3 |
| Chemical Name: | 4-fluoro-N-[6-[[4-(1-hydroxy-1-methylethyl)-1-piperidinyl]methyl]-1-[cis-4-[[(1-methylethyl)amino]carbonyl]cyclohexyl]-1H-benzimidazol-2-yl]-benzamide |
| Synonyms: | TSR-011 |
| 分子量: | 577.73 |
| 分子式: | C₃₃H₄₄FN₅O₃ |
| SMILES: | O=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Belizatinib 是一种有效的，可口服的ALK 和 TRKA、TRKB、TRKC 双重抑制剂，对野生型重组 ALK 的IC50值为0.7 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sachdev, J., Arkenau, H.T., Infante, J.R., et al.Phase (Ph) 1/2a study of TSR-011, a potent inhibitor of ALK and TRK, in advanced solid tumors including crizotinib-resistant ALK positive non-small cell lung cancerEur. J. Cancer50(6),165(2014)
