GW 441756
Cat. No.：YN380130
CAS No. ：504433-23-2
| 产品名称: | GW 441756 |
| CAS No.: | 504433-23-2 |
| Chemical Name: | 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one |
| Synonyms: | 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one;GW441756;2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-;GW 441756,1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyrid |
| 分子量: | 275.30 |
| 分子式: | C₁₇H₁₃N₃O |
| SMILES: | O=C1/C(C2=NC=CC=C2N1)=C\C3=CN(C)C4=C3C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW 441756是特异的高活性原肌球蛋白相关激酶A（TrkA）抑制剂，IC50为2 nM，对c-Raf1和CDK2几乎无活性。 |
| IC50和靶点: | [{name:"TrkA:2 nM (IC50)"}] |
| In Vitro: | |
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| Solvent & Solubility: |
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Jung, E.J., Lee, S.Y., and Kim, C.W.Proteomic analysis of novel targets associated with TrkA-mediated tyrosine phosphorylation signaling pathways in SK-N-MC neuroblastoma cellsProteomics13(2),355-367(2013)
Zhang, Q., Descamps, O., Hart, M.J., et al.Paradoxical effect of TrkA inhibition in Alzheimer's disease modelsJ. Alzheimers Dis.40(3),605-617(2014)
