7,8-Dihydroxyflavone
Cat. No.：YN380315
CAS No. ：38183-03-8
| 产品名称: | 7,8-Dihydroxyflavone |
| CAS No.: | 38183-03-8 |
| Chemical Name: | 7,8-dihydroxy-2-phenyl-4H-1-benzopyran-4-one |
| Synonyms: | 7,8-DHF |
| 分子量: | 254.24 |
| 分子式: | C₁₅H₁₀O₄ |
| SMILES: | O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 7,8-Dihydroxyflavone 是有效和选择性的TrkB激动剂，其模拟脑源性神经营养因子 (BDNF) 的生理作用。7,8-Dihydroxyflavone 有潜力用于各种神经疾病的研究。 |
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Jang, S.W., Liu, X., Yepes, M., et al.A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavoneProc. Natl. Acad. Sci. USA107(6),2687-2692(2010)
Andero, R., Heldt, S.A., Ye, K., et al.Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learningAm. J. Psychiatry168(2),163-172(2011)
Devi, L., and Ohno, M.7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's diseaseNeuropsychopharmacology37(2),434-444(2012)
Jiang, M., Peng, Q., Liu, X., et al.Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's diseaseHum. Mol. Genet.22(12),2462-2470(2013)
Kao, Y.C., Zhou, C., Sherman, M., et al.Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis studyEnviron. Health Perspect.106(2),85-92(1998)
Choi, J.Y., Kang, J.T., Park, S.J., et al.Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigsJ. Reprod. Dev.59(5),450-456(2013)
