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Tacalcitol monohydrate

Cat. No.:YN470029

  • CAS No. :93129-94-3

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    • 产品名称: Tacalcitol monohydrate
      CAS No.: 93129-94-3
      Chemical Name: 4-methylene-5Z-[2E-[(3aS)-octahydro-1R-[4R-hydroxy-1R,5-dimethylhexyl]-7aR-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol, monohydrate
      Synonyms:1,24(R)-Dihydroxyvitamin D3 monohydrate
      分子量:434.65
      分子式:C₂₇H₄₆O₄
      SMILES:CC([C@@H](CC[C@H]([C@@H](CC[C@]1/2[H])[C@@]1(C)CCCC2=C/C=C3C[C@@H](C[C@H](C/3=C)O)O)C)O)C.[H]O[H]
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Tacalcitol一水合物能通过调节钙离子促进骨发育。
      IC50和靶点:
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    • Holick, M.F.Vitamin D deficiencyN. Engl. J. Med.357(3),266-281(2007)

      Peterlik, M., Boonen, S., Cross, H.S., et al.Vitamin D and calcium insufficiency-related chronic diseases: An emerging world-wide public health problemInt. J. Environ. Res. Public Health6(10),2585-2607(2009)

      Bikle, D.D.1,25(OH)2D3-regulated human keratinocyte proliferation and differentiation: Basic studies and their clinical applicationJ. Nutr.125,1709S-1714S(1995)

      Leone, G., and Pacifico, A.Profile of clinical efficacy and safety of topical tacalcitolActa Biomed.76(1),13-19(2005)

      Prignano, F., Buggiani, G., and Lotti, T.Clinical evaluation of topical tacalcitol efficacy in extending the remission period between nb-UVB phototherapy cycles in psoriatic patientsActa Biomed.80,51-56(2009)

      Matsumoto, K., Hashimoto, K., Kiyoki, M., et al.Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytesJ. Dermatol.17(2),97-103(1990)

      Fukuoka, M., Ogino, Y., Sato, H., et al.Regulation of RANTES and IL-8 production in normal human dermal fibroblasts by active vitamin D3 (tacalcitol)Br. J. Pharmacol.124(7),1433-1438(1998)

      Yamanaka, K.I., Kakeda, M., Kitagawa, H., et al.1,24-Dihydroxyvitamin D3 (tacalcitol) prevents skin T-cell infiltrationBr. J. Dermatol.162(6),1206-1215(2010)

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