Maxacalcitol
Cat. No.：YN470030
CAS No. ：103909-75-7
规格
价格(RMB)
库存
| 产品名称: | Maxacalcitol |
| CAS No.: | 103909-75-7 |
| Chemical Name: | 4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol |
| Synonyms: | 马沙骨化醇; 22-Oxacalcitriol |
| 分子量: | 418.61 |
| 分子式: | C₂₆H₄₂O₄ |
| SMILES: | C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](OCCC(C)(O)C)C)CCC/2)[H])O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Maxacalcitol (22-Oxacalcitriol) 是非血钙维生素D3类似物和VDR样受体的配体。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Brown, A.J., Dusso, A.S., and Slatopolsky, E.Vitamin D analogues for secondary hyperparathyroidismNephrol. Dial. Transplant.17(Suppl),10-19(2002)
Brown, A.J., Ritter, C.R., Finch, J.L., et al.The noncalcemic analogue of vitamin D, 22-oxacalcitriol, suppresses parathyroid hormone synthesis and secretionJ. Clin. Invest.84(3),728-732(1989)
Akizawa, T., Suzuki, M., Akiba, T., et al.Long-term effect of 1,25-dihydroxy-22-oxavitamin D3 on secondary hyperparathyroidism in haemodialysis patients. One-year administration studyNephrol. Dial. Transplant.17(Suppl),28-36(2002)
Takahashi, H., Ibe, M., Kinouchi, M., et al.Similarly potent action of 1,25-dihydroxyvitamin D3 and its analogues, tacalcitol, calcipotriol, and maxacalcitol on normal human keratinocyte proliferation and differentiationJ. Dermatol. Sci.31(1),21-28(2003)
Okubo, Y., Natsume, S., Usui, K., et al.Combination therapy using maxacalcitol and corticosteroid lotions preliminary to monotherapy with maxacalcitol lotion for scalp psoriasisJ. Dermatolog. Treat.25(1),34-37(2012)
Seubwai, W., Wongkham, C., Puapairoj, A., et al.22-Oxa-1,25-dihydroxyvitamin D3 efficiently inhibits tumor growth in inoculated mice and primary histoculture of cholangiocarcinomaCancer116(23),5535-5543(2010)
