Vandetanib
Cat. No.：YN440072
CAS No. ：443913-73-3
规格
价格(RMB)
库存
| 产品名称: | Vandetanib |
| CAS No.: | 443913-73-3 |
| Chemical Name: | N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine |
| Synonyms: | 凡德他尼; ZD6474 |
| 分子量: | 475.35 |
| 分子式: | C₂₂H₂₄BrFN₄O₂ |
| SMILES: | FC1=CC(Br)=CC=C1NC2=NC=NC3=CC(OCC4CCN(CC4)C)=C(C=C23)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Vandetanib (D6474) 是一种有效的，具有口服活性的VEGFR2/KDR酪氨酸激酶抑制剂 (IC50=40 nM)。Vandetanib 也抑制VEGFR3/FLT4(IC50=110 nM) 和EGFR/HER1(IC50=500 nM)。 |
| IC50和靶点: | [{name:"VEGFR2:40 nM (IC50)"},{name: "VEGFR3:110 nM (IC50)"},{name: "EGFR/HER1:500 nM (IC50)"}] |
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Wedge, S.R., Ogilvie, D.J., Dukes, M., et al.ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administrationCancer Res.62(16),4645-4655(2002)
Davis, M.I., Hunt, J.P., Herrgard, S., et al.Comprehensive analysis of kinase inhibitor selectivityNat. Biotechnol.29(11),1046-1051(2011)
Ciardiello, F., Caputo, R., Damiano, V., et al.Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinaseClin. Cancer Res.9(4),1546-1556(2003)
Inoue, K., Torimura, T., Nakamura, T., et al.Vandetanib, an inhibitor of VEGF receptor-2 and EGF receptor, suppresses tumor development and improves prognosis of liver cancer in miceClin. Cancer Res.18(14),3924-3933(2012)
Rich, J.N., Sathornsumetee, S., Keir, S.T., et al.ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumorsClin. Cancer Res.11(22),8145-8157(2005)
