Brivanib (alaninate)
Cat. No.：YN440079
CAS No. ：649735-63-7
规格
价格(RMB)
库存
| 产品名称: | Brivanib (alaninate) |
| CAS No.: | 649735-63-7 |
| Chemical Name: | L-alanine, (1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethyl ester |
| Synonyms: | BMS-582664 |
| 分子量: | 441.46 |
| 分子式: | C₂₂H₂₄FN₅O₄ |
| SMILES: | O=C(O[C@@H](COC1=CN2C(C(OC3=C(C4=C(NC(C)=C4)C=C3)F)=NC=N2)=C1C)C)[C@@H](N)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brivanib alaninate (BMS-582664) 是一种 ATP 竞争性的VEGFR2抑制剂，IC50值为 25 nM；可以适度抑制 VEGFR1 和 FGFR1，对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。 |
| IC50和靶点: | [{name:"VEGFR2:25 nM (IC50)"}] |
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Bhide, R.S., Cai, Z.W., Zhang, Y.Z., et al.Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitorJ. Med. Chem.49(7),2143-2146(2006)
Cai, Z.W., Zhang, Y., Borzilleri, R.M., et al.Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215)J. Med. Chem.51(6),1976-1980(2008)
Lin, H.C., Huang, Y.T., Yang, Y.Y., et al.Beneficial effects of dual vascular endothelial growth factor receptor/fibroblast growth factor receptor inhibitor brivanib alaninate in cirrhotic portal hypertensive ratsJ. Gastroenterol. Hepatol.29(5),1073-1082(2014)
