Brivanib
Cat. No.：YN440080
CAS No. ：649735-46-6
规格
价格(RMB)
库存
| 产品名称: | Brivanib |
| CAS No.: | 649735-46-6 |
| Chemical Name: | (2R)-1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol |
| Synonyms: | 布立尼布; BMS-540215 |
| 分子量: | 370.38 |
| 分子式: | C₁₉H₁₉FN₄O₃ |
| SMILES: | FC1=C(OC2=NC=NN3C2=C(C(OC[C@H](O)C)=C3)C)C=CC4=C1C=C(C)N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brivanib (BMS-540215) 是一种 ATP 竞争性的VEGFR2抑制剂，IC50值为 25 nM；可以适度抑制 VEGFR-1 和 FGFR-1，对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍。 |
| IC50和靶点: | [{name:"VEGFR2:25 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Bhide, R.S., Cai, Z.W., Zhang, Y.Z., et al.Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitorJ. Med. Chem.49(7),2143-2146(2006)
Nakamura, I., Zakharia, K., Banini, B.A., et al.Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signalingPLoS One9(4),e92273(2014)
