Semaxinib
Cat. No.：YN440088
CAS No. ：204005-46-9
规格
价格(RMB)
库存
| 产品名称: | Semaxinib |
| CAS No.: | 204005-46-9 |
| Chemical Name: | 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one |
| Synonyms: | 司马沙尼; SU5416 |
| 分子量: | 238.28 |
| 分子式: | C₁₅H₁₄N₂O |
| SMILES: | O=C(NC1=CC=CC=C/21)C2=C/C3=C(C)C=C(C)N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Semaxinib (SU5416) 是有效，选择性的VEGFR(Flk-1/KDR) 抑制剂，IC50为 1.23 μM。 |
| IC50和靶点: | [{name:"Flk-1:1.23 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Fong, T.A.T., Shawver, L.K., Sun, L., et al.SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor typesCancer Res.59(1),99-106(1999)
Litz, J., Warshamana-Greene, G.S., Sulanke, G., et al.The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth andangiogenesis, in part by blocking Kit-mediated VEGF expressionLung Cancer46,283-291(2004)
Mologni, L., Sala, E., Cazzaniga, S., et al.Inhibition of RET tyrosine kinase by SU5416J. Mol. Endocrinol.37(2),199-212(2006)
