Tivozanib
Cat. No.：YN440127
CAS No. ：475108-18-0
规格
价格(RMB)
库存
| 产品名称: | Tivozanib |
| CAS No.: | 475108-18-0 |
| Chemical Name: | N-{2-Chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methylisoxazol-3-yl)urea; |
| Synonyms: | 替沃扎尼; AV-951; KRN951 |
| 分子量: | 454.86 |
| 分子式: | C₂₂H₁₉ClN₄O₅ |
| SMILES: | O=C(NC1=CC=C(C=C1Cl)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC4=NOC(C)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tivozanib (AV-951; KRN951) 是有效，选择性的VEGFR 1/2/3抑制剂，IC50值分别为0.21，0.16，and 0.24 nM。 |
| IC50和靶点: | [{name:"VEGFR1:0.21 nM (IC50)"},{name: "VEGFR2:0.16 nM (IC50)"},{name: "VEGFR3:0.24 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Nosov, D.A., et al.: J. Clinical. Oncol., 30, 1678 (2012)
Pal, S.K., et al., Molec. Cancer. Thr, 11, 526 (2012)
