KRN-633
Cat. No.：YN440190
CAS No. ：286370-15-8
规格
价格(RMB)
库存
| 产品名称: | KRN-633 |
| CAS No.: | 286370-15-8 |
| Chemical Name: | N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl-urea |
| Synonyms: | N-[2-氯-4-[(6,7-二甲氧基-4-喹唑啉基)氧基]苯基]-N'-丙基脲,KRN633 |
| 分子量: | 416.86 |
| 分子式: | C₂₀H₂₁ClN₄O₄ |
| SMILES: | ClC1=CC(OC2=NC=NC3=CC(OC)=C(C=C32)OC)=CC=C1NC(NCCC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KRN-633 是VEGFR的有效抑制剂，对VEGFR1，VEGFR2 和 VEGFR3的IC50值分别为170，160和125 nM。 |
| IC50和靶点: | [{name:"VEGFR1:170 nM (IC50)"},{name: "VEGFR2:160 nM (IC50)"},{name: "VEGFR3:125 nM (IC50)"}] |
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Fedorov, O., Marsden, B., Pogacic, V., et al.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinasesProc. Natl. Acad. Sci. USA104(51),20523-20528(2007)
Nakamura, K., Yamamoto, A., Kamishohara, M., et al.KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growthMol. Cancer Ther.3(12),1639-1649(2004)
