ZM 306416
Cat. No.:YN440290
产品名称: | ZM 306416 |
CAS No.: | 690206-97-4 |
Chemical Name: | N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine |
Synonyms: | CB 676475 |
分子量: | 333.74 |
分子式: | C₁₆H₁₃ClFN₃O₂ |
SMILES: | COC1=CC2=NC=NC(NC3=C(F)C=C(Cl)C=C3)=C2C=C1OC |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | ZM-306416 (CB 676475) 是VEGFR的有效抑制剂,对KDR 和 Flt的IC50值分别为0.1 和 2 μM。ZM-306416 也是EGFR的抑制剂,IC50值小于10 nM。 |
IC50和靶点: | [{name:"KDR:100 nM (IC50)"},{name: "Flt-1:2 μM (IC50)"}] |
In Vitro: | |
In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Hennequin, L.F., Thomas, A.P., Johnstone, C., et al.Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitorsJ. Med. Chem.42(26),5369-5389(1999)
Antczak, C., Mahida, J.P., Bhinder, B., et al.A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: Implications in drug discoveryJ. Biomol. Screen.17(7),885-899(2012)