PF-03814735
Cat. No.：YN440304
CAS No. ：942487-16-3
规格
价格(RMB)
库存
| 产品名称: | PF-03814735 |
| CAS No.: | 942487-16-3 |
| Chemical Name: | N-[2-[(1S,4R)-6-[[4-(cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-acetamide |
| Synonyms: | PF 03814735;PF03814735 |
| 分子量: | 474.48 |
| 分子式: | C₂₃H₂₅F₃N₆O₂ |
| SMILES: | O=C(CNC(C)=O)N1[C@@H]2C3=C(C=C(NC4=NC(NC5CCC5)=C(C(F)(F)F)C=N4)C=C3)[C@H]1CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-03814735是有效，有口服性，可逆的极光激酶A和B (aurora A/B) 的抑制剂，IC50值分别为0.8和5 nM。 |
| IC50和靶点: | [{name:"Aurora 1:0.8 nM (IC50)"},{name: "Aurora 2:5 nM (IC50)"},{name: "Flt-1:10 nM (IC50)"},{name: "FAK:22 nM (IC50)"},{name: "TrkA:30 nM (IC50)"},{name: "Met:100 nM (IC50)"},{name: "FGFR1:100 nM (IC50)"}] |
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| Solvent & Solubility: |
Jani, J.P., Arcari, J., Bernardo, V., et al.PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapyMol. Cancer Ther.9,883-894(2010)
Hook, K.E., Garza, S.J., Lira, M.E., et al.An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735Mol. Cancer Ther.11(3),710-719(2012)
