BIBF 1202
Cat. No.：YN440357
CAS No. ：894783-71-2
规格
价格(RMB)
库存
| 产品名称: | BIBF 1202 |
| CAS No.: | 894783-71-2 |
| Chemical Name: | (3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid |
| Synonyms: | BIBF-1202; BIBF 1202; BIBF1202. |
| 分子量: | 525.60 |
| 分子式: | C₃₀H₃₁N₅O₄ |
| SMILES: | O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIBF 1202是BIBF 1120的羧酸盐代谢物，抑制VEGFR2激酶的IC50值为62 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hilberg, F., Roth, G.J., Krssak, M., et al.BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacyCancer Res.68(12),4774-4782(2008)
Lin, D., Qiao, L.M., Zhang, Y.N., et al.Simultaneous determination of nintedanib and its metabolite by UPLC-MS/MS in rat plasma and its application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.117,173-177(2016)
