Fruquintinib
Cat. No.：YN440394
CAS No. ：1194506-26-7
规格
价格(RMB)
库存
| 产品名称: | Fruquintinib |
| CAS No.: | 1194506-26-7 |
| Chemical Name: | 6-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-3-benzofurancarboxamide |
| Synonyms: | 呋喹替尼; HMPL-013 |
| 分子量: | 393.39 |
| 分子式: | C₂₁H₁₉N₃O₅ |
| SMILES: | O=C(C1=C(C)OC2=CC(OC3=C4C=C(OC)C(OC)=CC4=NC=N3)=CC=C12)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fruquintinib (HMPL-013) 是有效，选择性的VEGFR 1/2/3抑制剂，IC50值分别为33，0.5，and 35 nM。 |
| IC50和靶点: | [{name:"VEGFR1:33 nM (IC50)"},{name: "VEGFR2:35 nM (IC50)"},{name: "VEGFR3:0.5 nM (IC50)"}] |
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| Solvent & Solubility: |
Sun, Q., Zhou, J., Zhang, Z., et al.Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapyCancer Biol. Ther.15(12),1635-1645(2014)
