Tanshinone IIA
Cat. No.：YN440421
CAS No. ：568-72-9
规格
价格(RMB)
库存
| 产品名称: | Tanshinone IIA |
| CAS No.: | 568-72-9 |
| Chemical Name: | 6,7,8,9-tetrahydro-1,6,6-trimethyl-phenanthro[1,2-b]furan-10,11-dione |
| Synonyms: | Dan Shen ketone |
| 分子量: | 294.34 |
| 分子式: | C₁₉H₁₈O₃ |
| SMILES: | O=C(C1=C2C=CC3=C1CCCC3(C)C)C(C4=C2OC=C4C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tanshinone IIA (Tan IIA) 是红根丹参根系中的主要脂溶性组合物之一。Tanshinone IIA 可以通过靶向VEGF/VEGFR2的蛋白激酶结构域来抑制血管生成。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Jang, S.I., Jeong, S.I., Kim, K.J., et al.Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-α, IL-1β and IL-6 in activated RAW 264.7 cellsPlanta Med.69(11),1057-1059(2003)
Kang, B.Y., Chung, S.W., Kim, S.H., et al.Inhibition of interleukin-12 and interferon-γ production in immune cells by tanshinones from Salvia miltiorrhizaImmunopharmacology49(3),355-361(2000)
Jin, U.H., Suh, S.J., Chang, H.W., et al.Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathwayJ. Cell. Biochem.104(1),15-26(2008)
Chiu, T.L., and Su, C.C.Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potentialInt. J. Mol. Med.25(2),231-236(2010)
Sung, H.J., Choi, S.M., Yoon, Y., et al.Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3Exp. Mol. Med.31(4),174-178(1999)
Liu, F., Yu, G., Wang, G., et al.An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of Tanshinone IIA against non-small cell lung cancerPLoS One7(7),42138(2012)
